Identifying web service integration challenges.

Web services technology promises well for the future of Business-to-Business integration (B2Bi). However, this technology is still in its infancy and the community is facing many challenges. In this paper we discuss some important B2Bi issues and look how web services could play their part in these. Currently, many web services related standards are being drawn up, but most of these are still immature and do not bring a real answer to the proposed challenges. Consequently, many topics for future research can be identified.Information; Requirements; Cognitive; Integration; Community;

Web services composition, execution and visualization.

Visualization; International;

Management and architecture click: The FAD(E)E Framework.

Enterprises are living things. They constantly need to be (re-)architected in order to achieve the necessary agility, alignment and integration. This paper gives a high-level overview of how companies can go about doing 'enterprise architecture' in the context of both the classic (isolated) enterprise and the Extended Enterprise. By discussing the goals that are pursued in an enterprise architecture effort we reveal some basic requirements that can be put on the process of architecting the enterprise. The relationship between managing and architecting the enterprise is discussed and clarified in the FAD(E)E, the Framework for the Architectural Development of the (Extended) Enterprise.Management; Architecture; Framework;

Extended enterprise architecture with the FADEE.

Business-to-Business integration (B2Bi) is considered to be not merely an IT-issue, but also a business problem. This paper draws attention to the challenges companies within an Extended Enterprise are confronted with when integrating their systems. We primarily pay attention to coordination problems that may arise. To overcome these problems we propose the use of Enterprise Architecture descriptions. We discuss the powers of using Enterprise Architecture descriptions in integration exercises. It will become clear that doing Enterprise Architecture is no longer an option; it is mandatory. Furthermore, we present the FADEE, the Framework for the Architectural Description of the Extended Enterprise. This framework gives an overview of how companies can apply the Zachman framework to do Enterprise Architecture in the realm of the Extended Enterprise.Architecture; Business-to-Business integration; Companies; Coordination; Enterprise architecture; Extended enterprise; Extended enterprise architecture framework; FADEE; Framework; Integration; Problems; Research; Systems;

Self Actualization in Hierarchy of Needs of a Princess as Seen in Meg Cabot\u27s the Princess Diaries

The process of self-actualization and self-esteem, especially self-confidence and self-image of the main character in the novel The Princess Diaries by Meg Cabot. This novel tells about Mia Thermopolis, the freshman student at Albert Einstein High School. Like many other teens, Mia has a problem in self-confidence because of her body posture that she thinks does not meet the standard in general. Mia is often labeled as a freak in her school. Her life problem is getting more complicated when she knows that she is a princess from a small country in Europe. Mia\u27s problem is a picture of teenage problems in general, the lack of self-confidence and the bad self-image. But Mia learns to solve all of her life problems in a mature way and wish that she can reach her self-actualization. In this research, the writer uses descriptive research as the method of collecting the data. As for the method of analyzing the data, the writer uses structural method by understanding the novel, the character of Mia Thermopolis. Data collection technique uses qualitative technique with taking note cards in finding relevant data to the subject of analysis. In data analysis technique, the writer uses technique by interpreting data. The results of this research are: 1) Mia\u27s self-actualization process at the end of the novel only reach the self-esteem phase. Mia is not yet fully reach her self-actualization, she often still being selfish and mostly still being emotional. 2) Mia\u27s self-confidence at the end of the novel is increase, Mia can accept her own self and flaws. 3) Mia\u27s self-image at the end of the novel changed. Mia learns that what is important is not the appearance but the personality inside an individual. As closing, even though this novel looks light where the story is only about teenager\u27s life problem in general, but there are a lot of lessons that can be applied in the daily life. Maybe not every girl can be a princess in one night, but the lessons about how can we be confidence are a lot in this novel

Setting up Extended Enterprises: A Data Aspects Framework

Nowadays, companies want to share information. When doing so, many issues have to be taken care of, and many options are available for most of these issues. Realizing B2Bi is a very complex task. It is the aim of this paper to make it possible to oversee the complexity of information sharing in a B2B context by structuring the issues that have to be taken care of in a new framework: the DA (Data Aspects) – framework; and by relating this framework to the existing FADEE framework

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD), ascertained within the European Early-Onset Dementia consortium. As control dataset, we sequenced 1,625 European control individuals and analyzed whole-exome sequence data of 2,274 German individuals (total n = 3,899). Association of rare SQSTM1 mutations was calculated in a meta-analysis of 4,332 FTLD and 10,240 control alleles. We identified 25 coding variants in FTLD patients of which 10 have not been described. Fifteen mutations were absent in the control individuals (carrier frequency < 0.00026) whilst the others were rare in both patients and control individuals. When pooling all variants with a minor allele frequency < 0.01, an overall frequency of 3.2 % was calculated in patients. Rare variant association analysis between patients and controls showed no difference over the whole protein, but suggested that rare mutations clustering in the UBA domain of SQSTM1 may influence disease susceptibility by doubling the risk for FTLD (RR = 2.18 [95 % CI 1.24-3.85]; corrected p value = 0.042). Detailed histopathology demonstrated that mutations in SQSTM1 associate with widespread neuronal and glial phospho-TDP-43 pathology. With this study, we provide further evidence for a putative role of rare mutations in SQSTM1 in the genetic etiology of FTLD and showed that, comparable to other FTLD/ALS genes, SQSTM1 mutations are associated with TDP-43 pathology

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

TAR DNA-binding protein 43 (TDP-43) inclusions are pathological hallmarks of patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Loss of TDP-43 in zebrafish engenders a severe muscle and vascular phenotype with a concomitant elevation of filamin C (FLNC) levels, an observation confirmed in the frontal cortex of FTLD-TDP patients. Here, we aimed to further assess the contribution of FLNC to frontotemporal dementia (FTD) etiology. We conducted a mutational screening of FLNC in a cohort of 529 unrelated Belgian FTD and FTD-ALS patients, and a control cohort of 920 unrelated and age-matched individuals. Additionally we performed an in-depth characterization of FLNC expression levels in FTD patients and a murine FTD model. In total 68 missense variants were identified of which 19 (MAF C) loss-of-function mutation. Increased FLNC levels were, to a lesser extent, also identified in a FLNC p.V831I variant carrier and in FTD patients with the p.R159H mutation in valosin-containing protein (VCP). The GRN-associated increase of FLNC was confirmed in the frontal cortex of aged Grn knockout mice starting at 16-18 months of age. Combined quantitative proteomic and bioinformatic analyses of the frontal cortex of FTD patients possessing elevated FLNC levels, identified multiple altered protein factors involved in accelerated aging, neurodegeneration and synaptogenesis. Our findings further support the involvement of aberrant FLNC expression levels in FTD pathogenesis. Identification of increased FLNC levels in aged Grn mice and impaired pathways related to aging and neurodegeneration, implies a potential role for FLNC in mediating or accelerating the aging process

Understanding factors which affect the organisation of data

nrpages: 41status: publishe

Research and Development in some Benelux Firms

nrpages: 49status: publishe